ABSTRACT
Introducción: El síndrome de Behcet, o enfermedad de Behcet, es un proceso autoinflamatorio crónico, poco frecuente, de etiología desconocida. Es una vasculitis que afecta arterias y venas de todos los calibres, con alteración de la función endotelial, que se expresa clínicamente con lesiones orgánicas variadas. En su fisiopatogenia intervienen factores genéticos, microbianos e inmunológicos. Los síntomas más comunes son las úlceras orales y genitales, inflamaciones oculares (uveítis, retinitis e iritis), lesiones de piel y artritis. Objetivo: Evaluar diversos marcadores de la respuesta inmune en paciente con síndrome de Behcet. Presentación del caso: Paciente masculino. 39 años de edad, con diagnóstico clínico de enfermedad de Behcet con reactantes de fase aguda y marcadores serológicos de autoinmunidad negativa. Las subpoblaciones linfocitarias están dentro de los valores referenciales, sin evidencias de activación linfocitaria. La presencia de una doble población de linfocitos B y los antecedentes familiares, sugieren la existencia de una población de linfocitos B de autoreconocimiento y la posible presencia de factores genéticos, respectivamente. El paciente respondió favorablemente a la terapia con esteroides. Conclusiones: El estudio apoya el criterio de que, en condiciones basales, no se detectan marcadores humorales de autoinmunidad, alteraciones de los valores de las subpoblaciones linfocitarias, ni evidencias de activación linfocitaria, pero no se puede excluir la presencia de una población de linfocitos B de autoreconocimiento(AU)
Introduction: Behcet's syndrome, also known as Behcet's disease is a chronic autoinflammatory process of low frequency and unknown etiology. It's an all sizes arteries and veins affecting vasculitis that causes an alteration of endothelial function and is expressed clinically by organ damage at various levels. Its pathogenesis involves genetic, microbial and immunological factors. The most common symptoms are oral and genital ulcers, eye inflammation (uveitis, iritis and retinitis), skin lesions and arthritis. Objective: to evaluate several inmunological markers in a patient with Behcet syndrome. Case presentation: 39 years old masculine patientwith clinical diagnosis of Behcet disease with negative acute phase reactants and serological authoinmunity markers and lymphocyte populations within referential range, without evidences of lymphocyte activation. The presence of a double B lymphocyte population and familial background, suggest the presence of a self recognitionB lymphocyte population and the probable presence of genetic factors, respectively. There was a good response to steroids treatment. Conclusions: The study supports the idea that at baseline, not humoral autoimmunity markers, changes in the values of lymphocyte subpopulations, and evidence of lymphocyte activation is detected, but can not exclude the presence of a population of B lymphocytes self-recognition(AU)
Subject(s)
Humans , Male , Middle Aged , Arthritis , Uveitis , Vasculitis , Autoimmunity , Behcet Syndrome , Genetics, Microbial , Immunologic Factors , Clinical DiagnosisABSTRACT
Pemphigua foliaceus is a rare, relatively mild and chronic variety of pemphigus which is characterized by superficial flaccid bullae which show acantholytic changes in the upper part of the epidermis histopathologically. We report herein five cases of pemphigus foliaceus. The patients had erythematous and crusted patches chiefly on face, chest and back areas, except for case 2 who had flaccid bullae on the upper extrimities. The diagnosis of all these patients were confirmed by immunofluorescence studies. Among these five patients, one was recognized as a rifampicin induced pemphigus foliaceus, and the other one revealed concurrent lesions of psoriasis.
Subject(s)
Humans , Diagnosis , Epidermis , Fluorescent Antibody Technique , Pemphigus , Psoriasis , Rifampin , ThoraxABSTRACT
For transferable and immunologieal studies on shock toxin (lethal faetor), a hind limbs ischemia tourniquet shock in rats has been examined. The blood of rats subjectd to severe shock transfused into mild shock rats has not significantly increased the mortality of the latter. Both the recruited plasma from shock rats and the plasma from the rats immunized with severe shork plasma had no therapeutic effects on tourniquet shock. It therefore appears that there is no specific and immunogenic shock toxin produced in the tourniquet shock in rats
ABSTRACT
Vinte e dois pacientes com leptospirose, internados no Hospital Couto Maia, Salvador, Bahia, foram investigados no sentido de se detectar possível envolvimento imunológico na patogênese da doença. A alergia cutânea na doença foi avaliada mediante injeção de 0,1 ml de suspensão de leptospiras inativadas, denominada Leptospirin, obtendo-se 91% de positividade. Em cinco pacientes procedeu-se à biopsia da lesão dérmica, sendo o estudo histopatológico e a imunofluorescência compatíveis com processo de hipersensibilidade retardada (tipo IV). O estudo das imunoglobulinas e complemento sérico mostraram elevação de IgG e IgM, e redução de Clq e Ca⢠A imunoeletroforese demonstrou redução da pré-albumina, ampliação de IgM (predominante) e IgG, além de aumento marcante da alfa-B-macroglobulína. Os achados sugerem que posstvers mecanismos imunolôgícos possam estar contribuindo na patogênese da doença (AU).